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Article

Protection of C. elegans from anoxia by HYL-2 ceramide synthase.

Science (New York, N.Y.) - 17 Apr 2009

Menuz Vincent, Howell Kate S, Gentina Sébastien, Epstein Sharon, Riezman Isabelle, Fornallaz-Mulhauser Monique, Hengartner Michael O, Gomez Marie, Riezman Howard, Martinou Jean-Claude

Abstract excerpt

Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival. We describe a pathway involving the HYL-2 ceramide synthase that acts independently of DAF-2. Loss of the ceramide synthase gene hyl-2 results in increased sensitivity of...

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Identifiers

PMID: 19372430
DOI: 10.1126/science.1168532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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