Article
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
Genetics - 1 Dec 1995
Dorman J B, Albinder B, Shroyer T, Kenyon C
Abstract excerpt
Recessive mutations in two genes, daf-2 and age-1, extend the lifespan of Caenorhabditis elegans significantly. The daf-2 gene also regulates formation of an alternative developmental state called the dauer. Here we asked whether these two genes function in the same or different lifespan pathways. We found that the longevity of both age-1 and daf-2 mutants requires the activities of the same two genes, daf-16 and...
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