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Article

Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16.

International journal of molecular sciences - 5 Jun 2018

Mi Xiang-Nan, Wang Li-Fang, Hu Yang, Pan Jun-Ping, Xin Yi-Rong, Wang Jia-Hui, Geng Hai-Ju, Hu Song-Hui, Gao Qin, Luo Huan-Min

Abstract excerpt

Genetic studies have elucidated mechanisms that regulate aging; however, there has been little progress in identifying drugs that retard ageing. Caenorhabditis elegans is among the classical model organisms in ageing research. Methyl 3,4-dihydroxybenzoate (MDHB) can prolong the life-span of C. elegans, but the underlying molecular mechanisms are not yet fully understood. Here, we report that MDHB prolongs the...

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Identifiers

PMID: 29874838
DOI: 10.3390/ijms19061670
PMCID: PMC6032309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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