Article
Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004
Small Kersten M, Mialet-Perez Jeanne, Seman Carrie A, Theiss Cheryl T, Brown Kari M, Liggett Stephen B
Abstract excerpt
The presynaptic alpha2C adrenergic receptors (AR) act to inhibit norepinephrine release in cardiac and other presynaptic nerves. We have recently shown that a genetic variant in the alpha2CAR coding region (Del322-325), which renders the receptor partially uncoupled from Gi, is a risk factor for heart failure. However, variability of heart failure phenotypes and a dominance of Del322-325 in those of African...
Topics
- Haplotypes
- Humans
- Myocardium
- Phenotype
- Polymorphism, Genetic
- Receptors, Adrenergic, alpha-2