Article
Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 1 Jan 2000
Gerson Myron C, Wagoner Lynne E, McGuire Nancy, Liggett Stephen B
Abstract excerpt
BACKGROUND: Patients with a deletion of 4 consecutive amino acids in the gene encoding for the alpha(2C)-adrenergic receptor (alpha(2C)Del322-325) have an increased prevalence of clinical heart failure, worse clinical status, and a lower left ventricular ejection fraction compared with patients without this deletion. We postulated that patients with the alpha(2C)Del322-325 polymorphism would have a compensatory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.