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Article

Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects.

Journal of hypertension - 1 Apr 2007

Kurnik Daniel, Muszkat Mordechai, Friedman Eitan A, Sofowora Gbenga G, Diedrich André, Xie Hong-Guang, Harris Paul A, Choi Leena, Wood Alastair J J, Stein C Michael

Abstract excerpt

BACKGROUND: The alpha2C-adrenergic receptor plays an important role in the regulation of the sympathetic nervous system and, therefore, blood pressure and heart rate. A deletion polymorphism in its gene (ADRA2C del322-325), ten times more common in black than white Americans, has been associated with a loss of function in vitro and, under controlled study conditions, raised blood pressure and catecholamine...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17351367
DOI: 10.1097/HJH.0b013e328017f6e9

Genes

DBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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