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Article

Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2000

Podlowski S, Wenzel K, Luther H P, Müller J, Bramlage P, Baumann G, Felix S B, Speer A, Hetzer R, Köpke K, Hoehe M R, Wallukat G

Abstract excerpt

A substantial body of evidence suggests involvement of the human beta1-adrenoceptor (beta1-AR) gene in the pathophysiology of dilated cardiomyopathy (DCM), a severe heart disease of significant public health impact. Beta1-AR-mediated signal transduction is dramatically altered due to downregulation, resulting in an impairment of myocardial response. The important role of genetic factors in idiopathic dilated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10794544
DOI: 10.1007/s001090000080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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