Article
Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy.
Kardiologia polska - 1 Mar 2009
Paczkowska Aleksandra, Szperl Małgorzata, Małek Łukasz, Mazurkiewicz Łukasz, Skóra Ewa, Grzybowski Jacek, Roszczynko Marta, Bilińska Zofia, Tesson Frederique, Ruzyłło Witold
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy (DCM) is a disorder characterised by dilation and impaired contractility of the left or both ventricles. This multifactorial disease has a strong genetic component with familial occurrence. A number of genes have been associated with idiopathic DCM (IDCM) including beta-1 (b1-AR) and beta-2 (b2-AR) adrenergic receptors. b1-AR and b2-AR are G-coupled proteins which play an...
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