Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy.

doi:10.1016/j.amjmed.2004.04.012

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Article

Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy.

The American journal of medicine - 1 Oct 2004

Forleo Cinzia, Resta Nicoletta, Sorrentino Sandro, Guida Pietro, Manghisi Andrea, De Luca Viviana, Romito Roberta, Iacoviello Massimo, De Tommasi Elisabetta, Troisi Federica, Rizzon Brian, Guanti Ginevra, Rizzon Paolo, Pitzalis Maria Vittoria

Abstract excerpt

PURPOSE: Increased sympathetic nervous system activation via the beta-adrenergic pathway influences the evolution of idiopathic dilated cardiomyopathy. We assessed the effects of beta-adrenergic receptor variants on heart failure in idiopathic dilated cardiomyopathy. METHODS: We prospectively analyzed 171 consecutive patients (mean [+/- SD] age, 49 +/- 14 years; 129 men) with idiopathic dilated cardiomyopathy who...

Topics

Adrenergic beta-Antagonists
Aged
Analysis of Variance
Cardiomyopathy, Dilated
Cause of Death
Disease Progression
Female
Genetic Variation
Heart Failure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heart Transplantation

Hospitalization

Humans

Italy

Male

Middle Aged

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Prognosis

Source

Open in PubMed

Identifiers

PMID: 15464701
DOI: 10.1016/j.amjmed.2004.04.012

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