Article
Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements.
Cellular signalling - 1 Aug 2006
Ma Jing, Cao Xinmin
Abstract excerpt
Regulated import of STAT proteins into the nucleus through the nuclear pores is a vital event. We previously identified Arg214/215 in the coiled-coil domain and Arg414/417 in the DNA binding domain involved in the ligand-induced nuclear translocation of Stat3. In this study, we investigated the mechanism for Stat3 nuclear transport. We report here that among five ubiquitously expressed human importin alphas,...
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