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Article

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3

26 May 2005

Abstract excerpt

Signal transducer and activator of transcription (STAT)3 is a member of a family of DNA-binding factors that function to induce expression of responsive genes. STAT3 can act as an oncogene, and its function has been shown to be critical for cellular transformation by a number of oncogenic tyrosine kinases. The role of STAT3 as a DNA-binding transcription factor naturally depends on its ability to gain entrance to...

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PMID: 15919823
DOI: 10.1073/pnas.0501643102

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