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Article

Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.

Journal of molecular biology - 10 Sept 2010

Nardozzi Jonathan, Wenta Nikola, Yasuhara Noriko, Vinkemeier Uwe, Cingolani Gino

Abstract excerpt

Interferon-gamma stimulation triggers tyrosine phosphorylation of the transcription factor STAT1 at position 701, which is associated with switching from carrier-independent nucleocytoplasmic shuttling to carrier-mediated nuclear import. Unlike most substrates that carry a classical nuclear local...

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Source

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Identifiers

PMID: 20643137
DOI: 10.1016/j.jmb.2010.07.013
PMCID: PMC2930068

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20643137-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Molecular basis for the recognition of phosphorylated STAT1 by importin alpha5.PMID 20643137Read ↗

Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements.Semantic proximity Read ↗

Dynamic Trafficking of STAT5 Depends on an Unconventional Nuclear Localization SignalSemantic proximity Read ↗

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3Semantic proximity Read ↗

Structural bases of unphosphorylated STAT1 association and receptor binding.Semantic proximity Read ↗

Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression.Semantic proximity Read ↗

A conserved motif in the linker domain of STAT1 transcription factor is required for both recognition and release from high-affinity DNA-binding sites.Semantic proximity Read ↗

A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin.Semantic proximity Read ↗

Unexpected functional role of the transactivation domain for nuclear import of STAT5Semantic proximity Read ↗

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.Semantic proximity Read ↗

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