Article
Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain.
Biochemical and biophysical research communications - 4 Aug 2006
Hoshino Akemi, Saint Fleur Shella, Fujii Hodaka
Abstract excerpt
Stat1 plays an essential role in signal transduction and gene expression of various cytokines including interferons (IFNs). Although the mechanism of cytokine-induced activation of Stat1 and transcriptional regulation of Stat1 gene expression have been established, post-transcriptional regulation of Stat1 protein expression is not fully understood. Here, we report identification of a mutant of Stat1 that has...
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