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Article

Signal transducer and activator of transcription 5a (STAT5a) represses mitochondrial gene expression through direct binding to mitochondrial DNA.

Biochemical and biophysical research communications - 5 Jul 2020

Chueh Fu-Yu, Chang Ying-Ling, Wu Shin-Yu, Yu Chao-Lan

Abstract excerpt

Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic transcription factors essential for cytokine signaling. Our previous study showed that interleukin-3 (IL-3) induced STAT5 translocation to mitochondria and binding to mitochondrial DNA (mtDNA) in vitro. In this report, we further demonstrated in vivo binding of endogenous STAT5a to mtDNA transcriptional control region and...

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PMID: 32446558
DOI: 10.1016/j.bbrc.2020.04.152

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