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Article

Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons.

Diabetes - 1 Oct 2013

Ren Hongxia, Plum-Morschel Leona, Gutierrez-Juarez Roger, Lu Taylor Y, Kim-Muller Ja Young, Heinrich Garrett, Wardlaw Sharon L, Silver Rae, Accili Domenico

Abstract excerpt

Successful development of antiobesity agents requires detailed knowledge of neural pathways controlling body weight, eating behavior, and peripheral metabolism. Genetic ablation of FoxO1 in selected hypothalamic neurons decreases food intake, increases energy expenditure, and improves glucose homeostasis, highlighting the role of this gene in insulin and leptin signaling. However, little is known about potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Forkhead Box Protein O1

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Share to Intracellular Signaling Peptides and Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 23835335
DOI: 10.2337/db13-0597
PMCID: PMC3781468

Genes

NPY
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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