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Developmental programming of hypothalamic melanocortin circuits

26 Apr 2022

Abstract excerpt

The melanocortin system plays a critical role in the central regulation of food intake and energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC), melanocortin receptors (MC4Rs), and the endogenous antagonist agouti-related peptide (AgRP). Pomc and Mc4r deficiency in rodents and humans causes early onset of obesity, whereas a loss of Agrp function is associated with leanness....

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PMID: 35474338
DOI: 10.1038/s12276-021-00625-8

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