Article
Caloric restriction selectively reduces the GABAergic phenotype of mouse hypothalamic proopiomelanocortin neurons.
The Journal of physiology - 15 Jan 2017
Jarvie Brooke C, King Connie M, Hughes Alexander R, Dicken Matthew S, Dennison Christina S, Hentges Shane T
Abstract excerpt
KEY POINTS: Hypothalamic proopiomelanocortin (POMC) neurons release peptide products that potently inhibit food intake and reduce body weight. These neurons also release the amino acid transmitter GABA, which can inhibit downstream neurons. Although the release of peptide transmitters from POMC neurons is regulated by energy state, whether similar regulation of GABA release might occur had not been examined. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.