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Article

Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations.

Journal of andrology - 1 Jan 2000

Miyagawa Yasushi, Nishimura Hiromi, Tsujimura Akira, Matsuoka Yasuhiro, Matsumiya Kiyomi, Okuyama Akihiko, Nishimune Yoshitake, Tanaka Hiromitsu

Abstract excerpt

Previously, we examined the relationship between protamine gene variations and human male infertility. In this study, we show specific variability in the transition nuclear protein genes (TNPs) of sterile male patients. Transition nuclear proteins (TPs) are major nuclear proteins that replace nuclear histones, leading to eventual substitution by protamines during human spermiogenesis. Analysis of the human TNP1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16291974
DOI: 10.2164/jandrol.05069

Genes

TNP1
TNP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations.PMID 16291974Read ↗

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