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Article

Analysis of sperm nuclear protein gene polymorphisms and DNA integrity in infertile men.

Systems biology in reproductive medicine - 1 Jun 2011

Venkatesh Sundararajan, Kumar Rajeev, Deka Deepika, Deecaraman Munuswamy, Dada Rima

Abstract excerpt

Sperm nuclear proteins, the protamines (PRM) and transition nuclear proteins (TNP) play a crucial role in sperm nuclear condensation. The compact packaging of sperm DNA by protamines maintains sperm genome integrity, which is prerequisite for normal sperm function. However the effect of nucleotide variations in PRM and TNP genes on sperm DNA integrity and male fertility is not clear. This case-control study was...

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Source

Identifiers

PMID: 21425891
DOI: 10.3109/19396368.2011.562960

Genes

PRM2
TNP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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