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Article

Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.

Molecular human reproduction - 1 Feb 2003

Tanaka Hiromitsu, Miyagawa Yasushi, Tsujimura Akira, Matsumiya Kiyomi, Okuyama Akihiko, Nishimune Yoshitake

Abstract excerpt

Although various genetic factors have been implicated in human male infertility, the causative genes for the different types of idiopathic male infertility have not been elucidated. Protamines, which are the major DNA-binding proteins in the sperm nucleus, package the DNA into the sperm head. Analysis of the human protamine-1 (PRM1) and -2 (PRM2) gene sequences in 226 sterile male patients and in 270...

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Source

Identifiers

PMID: 12569175
DOI: 10.1093/molehr/gag010

Genes

PRM2
PRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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