Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TNP1 haplotype - GCG is associated with azoospermia.

International journal of andrology - 1 Apr 2011

Khattri A, Bhushan S S, Sireesha V, Gupta N J, Chakravarty B N, Deendayal M, Prasad S, Singh L, Thangaraj K

Abstract excerpt

Transition nuclear proteins (TNP1 and TNP2) are the major nuclear proteins that replace somatic histones during spermatogenesis. TNPs are required for the maintenance of normal spermatogenesis. Moreover, spermatogenesis was found to be compromised in both Tnp1 and Tnp2 null mice. As no study is available on the role of these genes in Indian infertile men, we have sequenced the entire TNP1 and TNP2 genes in 320...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azoospermia
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to GCG gene

Share to Haplotypes

Share to Infertility, Male

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 20522125
DOI: 10.1111/j.1365-2605.2010.01072.x

Genes

TNP1
TNP2
GCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TNP1 haplotype - GCG is associated with azoospermia.PMID 20522125Read ↗

Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility.Semantic proximity Read ↗

Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations.Semantic proximity Read ↗

Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility.Semantic proximity Read ↗

Low-frequency germline variants across 6p22.2-6p21.33 are associated with non-obstructive azoospermia in Han Chinese men.Semantic proximity Read ↗

The PGAM4 gene in non-obstructive azoospermia.Semantic proximity Read ↗

Pathogenic variants screening in five non-obstructive azoospermia-associated genes.Semantic proximity Read ↗

PRM1 variant rs35576928 (Arg>Ser) is associated with defective spermatogenesis in the Chinese Han population.Semantic proximity Read ↗

Novel mutations of TEX11 are associated with non-obstructive azoospermia.Semantic proximity Read ↗

Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia.Semantic proximity Read ↗

Analysis of TATA-box binding protein associated factor 4b gene mutations in a Chinese population with nonobstructive azoospermia.Semantic proximity Read ↗

Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermiaSemantic proximity Read ↗

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.