Article
Mutations in the protamine locus: association with spermatogenic failure?
Molecular human reproduction - 1 Nov 2009
Imken L, Rouba H, El Houate B, Louanjli N, Barakat A, Chafik A, McElreavey K
Abstract excerpt
The protamine locus consists of a 28.5 kb region with a linear array of the protamine (PRM)1, PRM2, PRM3 and transition nuclear protein (TNP)2 genes. Several studies indicate an abnormal expression pattern of protamine genes associated with male infertility, although the molecular mechanism underlying this observation is unclear. Here, we determined the spectrum of DNA variants present in all four genes in men...
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