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Mutations in the protamine 1 gene associated with male infertility

9 May 2007

Abstract excerpt

In elongating spermatids, human sperm chromatin undergoes a complex compaction in which the transition proteins are extensively replaced by the protamine proteins. Several human studies demonstrate that expression of the protamine proteins is altered in some men with male infertility. For this study, we screened the PRM1 (protamine 1) gene for mutations in a large cohort of 281 men seeking infertility treatment....

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 17494104
DOI: 10.1093/molehr/gam031

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Mutations in the protamine 1 gene associated with male infertilityPMID 17494104Read ↗

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