Article
Disturbances of nuclear condensation in human spermatozoa: search for mutations in the genes for protamine 1, protamine 2 and transition protein 1.
Human reproduction (Oxford, England) - 1 Dec 1994
Schlicker M, Schnülle V, Schneppel L, Vorob'ev V I, Engel W
Abstract excerpt
During spermiogenesis, the successive replacement of the somatic histones by basic proteins, the transition proteins and protamines, allows normal sperm nuclear condensation. It was suggested that disturbances in nuclear condensation may result in male infertility. Here we report the first molecular analysis of the structure of three genes which code for germ cell-specific nuclear proteins, namely protamine 1...
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