Article
Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.
Development (Cambridge, England) - 1 May 2004
Goodrich Jennifer S, Clouse K Nicole, Schüpbach Trudi
Abstract excerpt
Heterogeneous nuclear ribonucleoproteins, hnRNPs, are RNA-binding proteins that play crucial roles in controlling gene expression. In Drosophila oogenesis, the hnRNP Squid (Sqd) functions in the localization and translational regulation of gurken (grk) mRNA. We show that Sqd interacts with Hrb27C, an hnRNP previously implicated in splicing. Like sqd, hrb27C mutants lay eggs with dorsoventral defects and Hrb27C...
Topics
- Animals
- Animals, Genetically Modified
- Body Patterning
- Chromosomes
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Heterogeneous-Nuclear Ribonucleoproteins
- Models, Biological
- Mutation
- Oocytes
- Oogenesis
- Ovary
- Phenotype