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Article

Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis.

Development genes and evolution - 1 Jul 2005

Norvell Amanda, Debec Alain, Finch Daniel, Gibson Lisa, Thoma Brandi

Abstract excerpt

The nuclear-cytoplasmic shuttling heterogeneous nuclear RNA-binding protein (hnRNP) Squid (Sqd) is required during Drosophila melanogaster oogenesis, where it plays a critical role in the regulation of the TGFalpha-like molecule Gurken (Grk). Three Sqd isoforms have been described, SqdA, S and B, and two of these, SqdA and SqdS, differentially function in grk mRNA nuclear export, cytoplasmic transport and...

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PMID: 15791421
DOI: 10.1007/s00427-005-0480-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis.PMID 15791421Read ↗

The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.Semantic proximity Read ↗

Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis.Semantic proximity Read ↗

Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.Semantic proximity Read ↗

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.Semantic proximity Read ↗

Glorund interactions in the regulation of gurken and oskar mRNAs.Semantic proximity Read ↗

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation.Semantic proximity Read ↗

Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

Sm proteins specify germ cell fate by facilitating oskar mRNA localization.Semantic proximity Read ↗

Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.Semantic proximity Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.Semantic proximity Read ↗

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