Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.

Abstract excerpt

Females mutant for the newly identified squid (sqd) gene are sterile and lay eggs that display only dorsal structures. The resulting embryos are also dorsalized even if fertilized by wild-type sperm. The gene acts midway through oogenesis at about the time dorsoventral (D/V) axis is established within the growing egg chamber. The sqd gene encodes at least three distinct proteins generated by alternative RNA...

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