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Article

Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis.

Genes & development - 1 Apr 1999

Norvell A, Kelley R L, Wehr K, Schüpbach T

Abstract excerpt

Heterogeneous nuclear RNA-binding proteins, hnRNPs, have been implicated in nuclear export of mRNAs in organisms from yeast to humans. A germ-line mutation in a Drosophila hnRNP, Squid (Sqd)/hrp40, causes female sterility as a result of mislocalization of gurken (grk) mRNA during oogenesis. Alternative splicing produces three isoforms, SqdA, SqdB, and SqdS. Here we show that these isoforms are not equivalent;...

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Identifiers

PMID: 10197986
DOI: 10.1101/gad.13.7.864
PMCID: PMC316593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis.PMID 10197986Read ↗

Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis.Semantic proximity Read ↗

Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.Semantic proximity Read ↗

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.Semantic proximity Read ↗

The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.Semantic proximity Read ↗

Glorund interactions in the regulation of gurken and oskar mRNAs.Semantic proximity Read ↗

The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.Semantic proximity Read ↗

Sm proteins specify germ cell fate by facilitating oskar mRNA localization.Semantic proximity Read ↗

Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases.Semantic proximity Read ↗

Multiple RNA regulatory pathways coordinate the activity and expression pattern of a conserved germline RNA-binding proteinSemantic proximity Read ↗

Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.Semantic proximity Read ↗

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