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Article

A role for KCC3 in maintaining cell volume of peripheral nerve fibers

31 Jan 2018

Abstract excerpt

in neurons to help maintain cell volume and intracellular chloride levels. A loss-of-function (LOF) of KCC3 causes Hereditary Motor Sensory Neuropathy with Agenesis of the Corpus Callosum (HMSN/ACC) in a population of individuals in the Charlevoix/Lac-Saint-Jean region of Quebec, Canada. A variety of mouse models have been created to understand the physiological and deleterious effects of a KCC3 LOF. Though this...

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PMID: 29366908
DOI: 10.1016/j.neuint.2018.01.009

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