Genetic diversity of T-helper cell epitopic regions of circumsporozoite protein of Plasmodium falciparum isolates from India.

doi:10.1016/j.trstmh.2005.07.012

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Article

Genetic diversity of T-helper cell epitopic regions of circumsporozoite protein of Plasmodium falciparum isolates from India.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 May 2006

Bhattacharya Pramatha R, Bhatia Vinay, Pillai C R

Abstract excerpt

Genetic variation in the T-helper cell epitopic regions (Th2R and Th3R) of circumsporozoite protein of 135 Plasmodium falciparum isolates collected from different epidemic and endemic regions of India was studied. Variation in the Th2R and Th3R regions was found to exhibit restricted polymorphism and can be grouped. The variations were not regionally biased, as different isolates collected from different regions...

Topics

Amino Acid Sequence
Animals
Antigenic Variation
Antigens, Protozoan
DNA, Protozoan
Epitopes, T-Lymphocyte
Genetic Variation
Geography
India
Malaria, Falciparum
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Polymerase Chain Reaction

Protozoan Proteins

Sequence Alignment

Sporozoites

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 16288791
DOI: 10.1016/j.trstmh.2005.07.012

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