Article
A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of P. falciparum parasites from western Thailand.
The Southeast Asian journal of tropical medicine and public health - 1 Jun 2004
Kumkhaek Chutima, Phra-ek Kooruethai, Singhasivanon Pratap, Looareesuwan Sornchai, Hirunpetcharat Chakrit, Brockman Alan, Grüner Anne Charlotte, Lebrun Nicolas, Rénia Laurent, Nosten François, Snounou Georges, Khusmith Srisin
Abstract excerpt
Allelic variation in the Plasmodium falciparum circumsporozoite protein (CS) gene has been determined by sequencing the immunodominant T-cell epitopes, Th2R and Th3R, from 95 isolates from two malaria-endemic areas in the west of Thailand. Comparison with a reference sequence revealed only non-synonymous point mutations in the two epitope regions. Point mutations were found outside these epitopes in a minority of...
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