Article
Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine.
PloS one - 1 Jan 2012
Zeeshan Mohammad, Alam Mohammad Tauqeer, Vinayak Sumiti, Bora Hema, Tyagi Rupesh Kumar, Alam Mohd Shoeb, Choudhary Vandana, Mittra Pooja, Lumb Vanshika, Bharti Praveen Kumar, Udhayakumar Venkatachalam, Singh Neeru, Jain Vidhan, Singh Pushpendra Pal, Sharma Yagya Dutta
Abstract excerpt
RTS,S is the most advanced malaria vaccine candidate, currently under phase-III clinical trials in Africa. This Plasmodium falciparum vaccine contains part of the central repeat region and the complete C-terminal T cell epitope region (Th2R and Th3R) of the circumsporozoite protein (CSP). Since naturally occurring polymorphisms at the vaccine candidate loci are critical determinants of the protective efficacy of...
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