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Article

Variation in the circumsporozoite protein of Plasmodium falciparum: vaccine development implications.

PloS one - 1 Jan 2014

Gandhi Kavita, Thera Mahamadou A, Coulibaly Drissa, Traoré Karim, Guindo Ando B, Ouattara Amed, Takala-Harrison Shannon, Berry Andrea A, Doumbo Ogobara K, Plowe Christopher V

Abstract excerpt

The malaria vaccine candidate RTS,S/AS01 is based on immunogenic regions of Plasmodium falciparum circumsporozoite protein (CSP) from the 3D7 reference strain and has shown modest efficacy against clinical disease in African children. It remains unclear what aspect(s) of the immune response elicited by this vaccine are protective. The goals of this study were to measure diversity in immunogenic regions of CSP,...

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Identifiers

PMID: 24992338
DOI: 10.1371/journal.pone.0101783
PMCID: PMC4081809

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Source receipt: pubmed, retrieved 7 Sept 2026.

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