Article
Genetic diversity and antibody responses against Plasmodium falciparum vaccine candidate genes from Chhattisgarh, Central India: Implication for vaccine development.
PloS one - 1 Jan 2017
Patel Priyanka, Bharti Praveen K, Bansal Devendra, Raman Rajive K, Mohapatra Pradyumna K, Sehgal Rakesh, Mahanta Jagadish, Sultan Ali A, Singh Neeru
Abstract excerpt
The genetic diversity in Plasmodium falciparum antigens is a major hurdle in developing an effective malaria vaccine. Protective efficacy of the vaccine is dependent on the polymorphic alleles of the vaccine candidate antigens. Therefore, we investigated the genetic diversity of the potential vaccine candidate antigens i.e. msp-1, msp-2, glurp, csp and pfs25 from field isolates of P.falciparum and determined the...
Topics
- Adolescent
- Adult
- Aged
- Antibodies, Protozoan
- Antigens, Protozoan
- Child
- Child, Preschool
- Female
- Genetic Variation
- Humans
- Immunoglobulin G
- India
- Infant
- Malaria Vaccines