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Article

Restricted T-cell epitope diversity in the circumsporozoite protein from Plasmodium falciparum populations prevalent in Iran.

The American journal of tropical medicine and hygiene - 1 Jun 2007

Zakeri Sedigheh, Avazalipoor Mehdi, Mehrizi Akram Abouei, Djadid Navid Dinparast, Snounou Georges

Abstract excerpt

Parasite genotyping studies have indicated that the Plasmodium falciparum populations circulating in Iran are genetically diverse and that multiple genotype infections are observed regularly. We wished to extend the analysis to the Pfcsp gene, coding for the dominant sporozoite surface antigen on which the leading malaria vaccine candidate RTS,S is based. Infected blood samples were collected mainly from Iranian,...

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PMID: 17556609

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