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Plasmodium falciparum: restricted polymorphism of T cell epitopes of the circumsporozoite protein in Brazil.

Experimental parasitology - 1 Nov 1990

Yoshida N, Di Santi S M, Dutra A P, Nussenzweig R S, Nussenzweig V, Enea V

Abstract excerpt

We examined the extent of variation of the 3' region of the circumsporozoite gene among Plasmodium falciparum isolates through amplification of a selected DNA fragment followed by DNA sequencing. A total of 32 isolates were analyzed, of which 24 were from Amazon endemic areas in Brazil and 8 from widely separated geographical regions in the world. Among Brazilian isolates only 2 variants were detected: 19...

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PMID: 1699781
DOI: 10.1016/0014-4894(90)90064-j

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