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Genetic diversity and population structure of genes encoding vaccine candidate antigens of Plasmodium vivax

14 Mar 2012

Abstract excerpt

BACKGROUND: A major concern in malaria vaccine development is genetic polymorphisms typically observed among Plasmodium isolates in different geographical areas across the world. Highly polymorphic regions have been observed in Plasmodium falciparum and Plasmodium vivax antigenic surface proteins such as Circumsporozoite protein (CSP), Duffy-binding protein (DBP), Merozoite surface protein-1 (MSP-1), Apical...

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PMID: 22417572
DOI: 10.1186/1475-2875-11-68

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