Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genes required for vacuolar acidity in Saccharomyces cerevisiae.

Genetics - 1 Jul 1992

Preston R A, Reinagel P S, Jones E W

Abstract excerpt

Mutations that cause loss of acidity in the vacuole (lysosome) of Saccharomyces cerevisiae were identified by screening colonies labeled with the fluorescent, pH-sensitive, vacuolar labeling agent, 6-carboxyfluorescein. Thirty nine vacuolar pH (Vph-) mutants were identified. Four of these contained mutant alleles of the previously described PEP3, PEP5, PEP6 and PEP7 genes. The remaining mutants defined eight...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Fluoresceins
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Hydrogen-Ion Concentration

Share to Mutagenesis

Share to Saccharomyces cerevisiae

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 1628805
DOI: 10.1093/genetics/131.3.551
PMCID: PMC1205029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes required for vacuolar acidity in Saccharomyces cerevisiae.PMID 1628805Read ↗

Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.Semantic proximity Read ↗

Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis.Semantic proximity Read ↗

A genomic screen for yeast vacuolar membrane ATPase mutants.Semantic proximity Read ↗

Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPase.Semantic proximity Read ↗

Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast.Semantic proximity Read ↗

Genetic interaction with vps8-200 allows partial suppression of the vestigial vacuole phenotype caused by a pep5 mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mutants defective in vacuolar acidification and protein sorting.Semantic proximity Read ↗

Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification.Semantic proximity Read ↗

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.Semantic proximity Read ↗

Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.