A genomic screen for yeast vacuolar membrane ATPase mutants.

doi:10.1534/genetics.105.042812

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Article

A genomic screen for yeast vacuolar membrane ATPase mutants.

Genetics - 1 Aug 2005

Sambade Maria, Alba Mercedes, Smardon Anne M, West Robert W, Kane Patricia M

Abstract excerpt

V-ATPases acidify multiple organelles, and yeast mutants lacking V-ATPase activity exhibit a distinctive set of growth defects. To better understand the requirements for organelle acidification and the basis of these growth phenotypes, approximately 4700 yeast deletion mutants were screened for growth defects at pH 7.5 in 60 mm CaCl(2). In addition to 13 of 16 mutants lacking known V-ATPase subunits or assembly...

Topics

Adenosine Triphosphatases
Alkaline Phosphatase
Calcineurin
Gene Deletion
Genome, Fungal
Hydrogen-Ion Concentration
Microscopy, Fluorescence
Mutation
Quinacrine
Saccharomyces cerevisiae
Vacuolar Proton-Translocating ATPases
Vacuoles

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Identifiers

PMID: 15937126
DOI: 10.1534/genetics.105.042812
PMCID: PMC1365767

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