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Article

Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis.

The Journal of biological chemistry - 12 Aug 2011

Tarsio Maureen, Zheng Huimei, Smardon Anne M, Martínez-Muñoz Gloria A, Kane Patricia M

Abstract excerpt

In yeast cells, subunit a of the vacuolar proton pump (V-ATPase) is encoded by two organelle-specific isoforms, VPH1 and STV1. V-ATPases containing Vph1 and Stv1 localize predominantly to the vacuole and the Golgi apparatus/endosomes, respectively. Ratiometric measurements of vacuolar pH confirm that loss of STV1 has little effect on vacuolar pH. Loss of VPH1 results in vacuolar alkalinization that is even more...

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PMID: 21669878
DOI: 10.1074/jbc.M111.251363
PMCID: PMC3151054

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