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Article

Genetic interaction with vps8-200 allows partial suppression of the vestigial vacuole phenotype caused by a pep5 mutation in Saccharomyces cerevisiae.

Genetics - 1 Jan 1998

Woolford C A, Bounoutas G S, Frew S E, Jones E W

Abstract excerpt

pep5 mutants of Saccharomyces cerevisiae accumulate inactive precursors to the vacuolar hydrolases. In addition, they show a vestigial vacuole morphology and a sensitivity to growth on media containing excess divalent cations. This pleiotropic phenotype observed for pep5::TRP1 mutants is partially suppressed by the vps8-200 allele. pep5::TRP1 vps8-200 mutants show near wild-type levels of mature-sized soluble...

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Identifiers

PMID: 9475722
DOI: 10.1093/genetics/148.1.71
PMCID: PMC1459777

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