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Article

Characterization of Schizosaccharomyces pombe mutants defective in vacuolar acidification and protein sorting.

Molecular genetics and genomics : MGG - 1 Mar 2004

Iwaki T, Goa T, Tanaka N, Takegawa K

Abstract excerpt

The vacuolar H+-ATPases (V-ATPases) are ATP-dependent proton pumps responsible for acidification of intracellular compartments in eukaryotic cells. To investigate the functional roles of the V-ATPase in Schizosaccharomyces pombe, the gene vma1 encoding subunit A or vma3 encoding subunit c was disrupted. Both deletion mutants lost the capacity for vacuolar acidification in vivo, and showed sensitivity to neutral...

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PMID: 14735354
DOI: 10.1007/s00438-003-0971-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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