Article
Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.
The Journal of cell biology - 1 Oct 1994
Munn A L, Riezman H
Abstract excerpt
Yeast mutants that are defective in acidification of the lysosome-like vacuole are able to grow at pH 5.5, but not at pH 7. Here, we present evidence that endocytosis is required for this low pH-dependent growth and use this observation to develop a screen for mutants defective in endocytosis. By isolating mutants that cannot grow when they lack the 60-kD vacuolar ATPase subunit (encoded by the VAT2 gene), we...
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