Article
Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.
The Journal of cell biology - 1 Oct 1994
Munn A L, Riezman H
Abstract excerpt
Yeast mutants that are defective in acidification of the lysosome-like vacuole are able to grow at pH 5.5, but not at pH 7. Here, we present evidence that endocytosis is required for this low pH-dependent growth and use this observation to develop a screen for mutants defective in endocytosis. By...
Topics
- Carboxypeptidases
- Cathepsin A
- Culture Media
- Endocytosis
- Genes, Fungal
- Genes, Lethal
- Hydrogen-Ion Concentration
- Isoquinolines
- Mating Factor
- Mutation
- Peptides
- Proton-Translocating ATPases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Temperature
- Vacuoles