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Article

Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification.

Molecular and cellular biology - 1 Mar 1998

Oluwatosin Y E, Kane P M

Abstract excerpt

Mutants of Saccharomyces cerevisiae that lack vacuolar proton-translocating ATPase (V-ATPase) activity show a well-defined set of Vma- (stands for vacuolar membrane ATPase activity) phenotypes that include pH-conditional growth, increased calcium sensitivity, and the inability to grow on nonfermentable carbon sources. By screening based on these phenotypes and the inability of vma mutants to accumulate the...

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Identifiers

PMID: 9488470
DOI: 10.1128/MCB.18.3.1534
PMCID: PMC108868

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