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Article

Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Nelson H, Nelson N

Abstract excerpt

The main function of vacuolar H(+)-ATPases in eukaryotic cells is to generate proton and electrochemical gradients across the membranes of the vacuolar system. The enzyme is composed of a catalytic sector with five subunits (A-E) and a membrane sector containing at least two subunits (a and c). We disrupted two genes of this enzyme, in yeast cells, one encoding a subunit of the membrane sector (subunit c) and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2139726
DOI: 10.1073/pnas.87.9.3503
PMCID: PMC53929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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