Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.

doi:10.1073/pnas.87.9.3503

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Article

Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Nelson H, Nelson N

Abstract excerpt

The main function of vacuolar H(+)-ATPases in eukaryotic cells is to generate proton and electrochemical gradients across the membranes of the vacuolar system. The enzyme is composed of a catalytic sector with five subunits (A-E) and a membrane sector containing at least two subunits (a and c). W...

Topics

Cloning, Molecular
Genes, Fungal
Genes, Lethal
Macromolecular Substances
Models, Biological
Molecular Weight
Mutation
Proton-Translocating ATPases
Restriction Mapping
Saccharomyces cerevisiae
Vacuoles

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