Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A repressive epigenetic domino effect confers susceptibility to breast epithelial cell transformation: implications for predicting breast cancer risk.

Cancer research - 1 Nov 2006

Bistulfi Gaia, Pozzi Silvia, Ren MingQiang, Rossetti Stefano, Sacchi Nicoletta

Abstract excerpt

Retinoic acid (RA) is a master epigenetic regulator that plays a pivotal role in both breast morphogenesis and development. Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2 (RARbeta2) and the cellular retinol-binding protein 1 (CRBP1). Specifically, an impaired RA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Epithelial Cells

Share to Gene Silencing

Share to Receptors, Retinoic Acid

Share to Retinol-Binding Proteins

Share to Tretinoin

Source

Identifiers

PMID: 17079450
DOI: 10.1158/0008-5472.CAN-06-1052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A repressive epigenetic domino effect confers susceptibility to breast epithelial cell transformation: implications for predicting breast cancer risk.PMID 17079450Read ↗

Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance.Semantic proximity Read ↗

Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.Semantic proximity Read ↗

Promoter Methylation of the Retinoic Acid Receptor Beta2 (RARβ2) Is Associated with Increased Risk of Breast Cancer: A PRISMA Compliant Meta-Analysis.Semantic proximity Read ↗

Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signalingSemantic proximity Read ↗

Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial‐to‐mesenchymal transition and disruption of mammary acinar structuresSemantic proximity Read ↗

Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer.Semantic proximity Read ↗

Retinoic Acid-Induced 2 Contributes to Proficient Homologous Recombination and Maintains Genomic Stability in Breast CancerSemantic proximity Read ↗

Methylation and Silencing of the Retinoic Acid Receptor- 2 Gene in Breast CancerSemantic proximity Read ↗

The molecular physiology of nuclear retinoic acid receptors. From health to diseaseSemantic proximity Read ↗

Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancerSemantic proximity Read ↗

Transient CB2 receptor activation triggers irreversible luminal differentiation via chromatin remodeling in breast cancerSemantic proximity Read ↗

RRIG1 Mediates Effects of Retinoic Acid Receptor β2 on Tumor Cell Growth and Gene Expression through Binding to and Inhibition of RhoASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.