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Article

Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.

PloS one - 1 Jan 2009

Corlazzoli Francesca, Rossetti Stefano, Bistulfi Gaia, Ren Mingqiang, Sacchi Nicoletta

Abstract excerpt

BACKGROUND: Chromatin adapts and responds to extrinsic and intrinsic cues. We hypothesize that inheritable aberrant chromatin states in cancer and aging are caused by genetic/environmental factors. In previous studies we demonstrated that either genetic mutations, or loss, of retinoic acid receptor alpha (RARalpha), can impair the integration of the retinoic acid (RA) signal at the chromatin of RA-responsive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19173001
DOI: 10.1371/journal.pone.0004305
PMCID: PMC2627936

Genes

CRABP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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