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Article

Linkage analysis of maturity-onset diabetes of the young with microsatellite polymorphisms. No linkage to ADA or GLUT2 genes in two families.

Diabetes - 1 Aug 1992

Patel P, Lo Y M, Hattersley A, Bell G I, Tybjaerg-Hansen A, Nerup J, Turner R C, Wainscoat J S

Abstract excerpt

MODY is a form of NIDDM inherited as an autosomal dominant condition. We studied the linkage of MODY to two loci: ADA and GLUT2 in two large pedigrees with nonradioactive microsatellite polymorphic systems. A positive linkage of ADA to MODY was recently demonstrated in the large RW pedigree. Formal linkage analysis excluded a tight linkage between ADA and MODY with a LOD score of -5.82 and -2.24 at a...

Topics

Adenosine Deaminase
Alleles
Base Sequence
Diabetes Mellitus, Type 2
Female
Genetic Linkage
Humans
Lod Score
Male
Molecular Sequence Data
Monosaccharide Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 1628771
DOI: 10.2337/diab.41.8.962

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1628771-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Linkage analysis of maturity-onset diabetes of the young with microsatellite polymorphisms. No linkage to ADA or GLUT2 genes in two families.PMID 1628771Read ↗

Linkage of type 2 diabetes to the glucokinase gene.Semantic proximity Read ↗

Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.Semantic proximity Read ↗

Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase.Semantic proximity Read ↗

Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes.Semantic proximity Read ↗

Linkage and molecular scanning analyses of MODY3/hepatocyte nuclear factor-1 alpha gene in typical familial type 2 diabetes: evidence for novel mutations in exons 8 and 10.Semantic proximity Read ↗

No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.Semantic proximity Read ↗

Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.Semantic proximity Read ↗

Sib-pair analysis of adenosine deaminase locus in NIDDM.Semantic proximity Read ↗

Localization of MODY3 to a 5-cM region of human chromosome 12.Semantic proximity Read ↗

Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.Semantic proximity Read ↗

New susceptibility locus for NIDDM is localized to human chromosome 20q.Semantic proximity Read ↗

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.Semantic proximity Read ↗

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