Article
Sib-pair analysis of adenosine deaminase locus in NIDDM.
Diabetes - 1 Dec 1992
Baroni M G, Alcolado J C, Needham E W, Pozzilli P, Stocks J, Galton D J
Abstract excerpt
Recently, linkage between the ADA gene locus and MODY, a subtype of NIDDM, has been reported. The possibility that the region of chromosome 20q containing the ADA locus also may play a role in susceptibility to NIDDM needs to be investigated. Therefore, we examined the linkage between the ADA locus and NIDDM in affected siblings of 50 European white diabetic pedigrees--21 Italian and 29 British. Departure from...
Topics
- Adenosine Deaminase
- Alleles
- Base Sequence
- Chromosomes, Human, Pair 20
- Diabetes Mellitus, Type 2
- Gene Frequency
- Humans
- Italy
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic