Article
Linkage and molecular scanning analyses of MODY3/hepatocyte nuclear factor-1 alpha gene in typical familial type 2 diabetes: evidence for novel mutations in exons 8 and 10.
The Journal of clinical endocrinology and metabolism - 1 Jun 1998
Elbein S C, Teng K, Yount P, Scroggin E
Abstract excerpt
Mutations of the hepatocyte nuclear factor-1 alpha (HNF1 alpha) gene are an important cause of autosomal dominant diabetes with onset before age 25 yr [maturity-onset diabetes of the young (MODY)], and some regions of the HNF1 alpha gene appear to be hot spots for mutations. To evaluate the role...
Topics
- Adolescent
- Adult
- Aged
- Animals
- Conserved Sequence
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2
- Exons
- Female
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Humans
- Lod Score
- Male
- Middle Aged
- Mutation
- Nuclear Proteins